Synthesis is primarily hindered due to the inhibition of the mTOR signaling pathway (manifested as downregulation of PI3K/Akt/mTORc1 activity), leading to reduced protein synthesis [37]
In addition, according to observational and experimental data, DPP4 inhibitors [10, 11], sulfonylureas [11, 52], and insulin [53], are unlikely to slow cognitive decline beyond the benefits of glycemic control in diabetes without dementia
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